Detailed Product Description

COA & Sales Specification  

INDUSTRY/FOOD GRADE    

APPEARANCE               yellow to brown powder

ASSAY (DRY BASIS)          97.0 - 101.5% (on dry basis)

LOOSE ON DRYING          1.0% max

Guarantee peroid            

CAS No.                   599-79-1

Molecular Formula        C₁₈H₁₄N₄O₅S

Molecular Weight         398.39

Physical & Chemical Character        

PHYSICAL STATE         yellow to brown powder

MELTING POINT          240 - 245 C (Decomposes)

BOILING POINT          

SPECIFIC GRAVITY       

SOLUBILITY IN WATER    Insoluble (soluble in dilute alkaline solution)

SOLVENT SOLUBILITY   

AUTOIGNITION              

HAZARD CLASS             

PH                       

STABILITY                Stable under normal conditions.

More Information        

Sulfonamide is an organic sulfur compounds containing the radical -SO2NH2 (the amides of sulfonic acids). Its molecular structure is similar to p-Aminobenzoic acid (PABA) which is needed in bacteria organisms as a substrate of the enzyme dihydropteroate synthetase for the synthesis of tetrahydrofolic acid (THF). Sulfonamides, derived from chiefly sulfanilamide, are capable of interfering with the metabolic processes in bacteria that require PABA. They act as antimicrobial agents by inhibiting bacterial growth and activity and called sulfa drugs. They are used in the prevention and treatment of bacterial infections, diabetes mellitus, edema, hypertension, and gout. Sulfa drug includes;

• Topical sulfonamides: sulfacetamide; silver sulfadiazine; mafenide; 
• Rapidly absorbed and eliminated sulfonamides: sulfisoxazole diolamine; sulfadiazine; sulfamethoxazole;
• Hydrophylic sulfonamides: phtalylsulfacetamide; phtalylsulfathiazole; sulfasalazine; sulfaguanidine;
• Long lasting sulfonamides: sulfadoxine; 
• Others: sulfamazole; sulfamazone; sulfametopirazine; sulfametoxypiridazine; sulfametrol; succinylsulfathiazole; 

Sulfasalazine, a sulfonamide derivative, is used as an antimicrobial agent by inhibiting bacterial growth and activity mainly in the treatment of ulcerative colitis and in the treatment of rheumatoid arthritis, administered orally. It is a yellow to brown powder; insoluble in water; decomposes at melting point 240 C.